The follicular phase of the female menstrual cycle includes the maturation of ovarian follicles to prepare one of them for release during ovulation. During the proliferative phase, the endometrial stroma is usually densely cellular, and the stromal cells are small and oval with hyperchromatic nuclei and indistinct cytoplasm and cell borders. 8 - other international versions of ICD-10 N85. A result of disordered or crowded glands is common with anovulatory cycles due to prolonged estrogen stimulation without postovulatory progesterone exposure. 40%) cases of disordered proliferative endometrium and 44 (10. People between 50 and 60 are most likely to develop endometrial hyperplasia. Disordered proliferative pattern resembles a simple hyperplasia, but the process is focal rather than diffuse. 1%) and disordered proliferative endometrium. Tamoxifen at 20 mg/d exerts a time-dependent proliferative effect on the endometrium, particularly in premenopausal and early postmenopausal women. The secondary histologic features of chronic endometritis like gland architectural irregularity, spindled stroma, stromal edema and hemorrhage with the. It occurs from day zero to day 14. Endometrial hyperplasia was the most common histopathological finding and was seen in 25% patients, followed by secretory endometrium in 16. During this phase, the endometrial glands grow and become. Disordered proliferative endometrium is an exaggeration of the normal proliferative phase cause by failed ovulation or minor prolongation of estrogen stimulation. 2 Microscopic. Noninflammatory disorders of female genital tract. Proliferative activity is relatively common in postmenopausal women ~25%. 5 years; P<. Can you please suggest is the D&C report normal or not. Disordered proliferative endometrium is a non-cancerous change that develops in the tissue that lines the inside of the uterus. The endometrium is the fleshy tissue in the womb that becomes a rich bed of blood vessels that would support a pregnancy, building during the proliferative (growing) phase before later dissolving into menstrual flow when. The changes associated with anovulatory bleeding, which are referred to as. By the late proliferative phase (days 11–14), the endometrium develops a thick trilaminar structure with a thin echogenic inner line and outer basilar layers and a hypoechoic central rim (Fig. The last menstrual period should be correlated with EMB results. Ultrasound. Proliferative endometrium on the other hand was seen in only 6. Proliferative-phase endometrial CD138 + cells may be an adverse indicator for pregnancy outcomes in fresh IVF/ICSI cycles, with a certain value in predicting non-pregnancy. During the menstrual cycle, the endometrium cycles through a proliferative phase (growth phase) and secretory phase in response to hormones (estrogen and progesterone) made and released by the ovaries. 43%). Doctoral Degree. D & C report shows no malignancy is there. 8% , 46. And you spoke to someone at the Dept. Proliferative endometrium with no atypia or malignancy Proliferative endometrium with no atypia or malignancy MDPA 100mg BD for 6 to 8 weeks 8 weeks 3. breakdown. 7%) followed by secretory phase (22. It results from the unopposed estrogenic stimulation of the endometrial tissue with a relative deficiency of the counterbalancing. Secretory phase endometrium was found in 13. Disordered proliferative pattern lies at one end of the spectrum of. I'm 51, no period 8 months, spotting almost every day for year. During the proliferative phase, the endometrium responds to the endocrine environment to undergo extensive proliferation. Learn how we can help. g. During the proliferative phase, the endometrium responds to the endocrine environment to undergo extensive proliferation. Disordered proliferative endometrium accounted for 5. Disordered proliferative endometrium can cause spotting between periods. Endometrial hyperplasia without atypia (as in the 2020 WHO classification) is defined as the proliferation of endometrial glands of irregular size and shape without significant cytological atypia. Between the 19th and 23rd day of a typical 28-day cycle (the mid-secretory phase), the degree of glandular secretion increases. 06 Hyperplasia 6 3. Abstract. proliferative endometrium, followed by disordered proliferation comprising 58 (29%) patients [Figure 2]. Objective: We clarified cytology in metaplastic changes recognized in endometrial glandular and stromal breakdown (EGBD). 1%) each. 7. ICD-10-CM Coding Rules. Histopathology showed 16 cases of disordered proliferative endometrium, 12 cases of PEB, 13 cases of proliferative phases, five cases of secretory phase, threePerhaps a better usage refers to a proliferative phase endometrium that does not seem appropriate for any one time in the menstrual cycle but is not abnormal enough to be considered hyperplastic. 8% , 46. On pap tests this is associated with the classic double contoured balls of endometrial epithelium and stroma. Balls of cells? Blue - likely menstrual (stromal. 2%), and. The stromal cells are arranged in a compact manner. simple proliferative no nuclear atypia, endometrial Disordered focally dilated & can be thought +/-evidence of hyperplasia, proliferative irregular glands of a waffle shedding (stromal proliferative endometrium (usu. The other main leukocytes of normal endometrium are CD56 + uterine natural killer (uNK) cells which account for 2% of stromal cells in proliferative endometrium, 17% during late secretory phase and more than 70% of endometrial leukocytes at the end of the first trimester of pregnancy where they play a role in. Mid Proliferative phase showed longer curved glands. Symptoms?: I assume this was a result of an endometrial biopsy done for heavy or irregular bleeding. Metaplasia is defined as a change of one cell type to another cell type. What does my biopsy result mean? chronic endometris in proliferative phase endometrium with glandular and stromal breakdown. The endometrium must be destroyed or resected to the level of the basalis ,… This technique may be performed during either the proliferative or secretory phase of the cycle. This diagnosis means that after examining your tissue sample under the microscope, your pathologist saw irregular and dilated endometrial glands in the proliferative phase (growing phase). Should be easily regulated with hormones such as low dose b. Conventional endometrial, endocervical, or adenomyomatous pedunculated, or sessile lesion with histologic features diagnostic of polyp Glands: Glandular architecture out of phase with the background endometrium Angulated, tubular or cystically dilated Usually endometrioid in type: inactive, proliferative or functionalICD-10-CM Code. 1 b) [ 6 ]. 6 kg/m 2; P<. 1002/dc. 4% cases. endometrial polyp 227 (9. 02 - other international versions of ICD-10 N85. 72 mm w/ polyp. The diagnosis of disordered proliferative phase should be reserved for cases in which assessment is based on intact, well-oriented fragments of tissue. Conclusion: FIGO/PALM-COEIN classification will be helpful in deciding treatment of AUB cases. 01) N85. In patients who presented with metrorrhagia, secretory phase endometrium was the most common histopathological nding accounting for 34. 6k views Reviewed Dec 27, 2022. Endometrium in proliferative phase, secretory phase, endometrial polyps, and disordered proliferative endometrium were studied for the presence of plasma cells. Review authors excluded 26 participants as they had a histological diagnosis of "Disordered proliferative endometrium" or "Endometrioid endometrial carcinoma" at baseline, leaving 17 participants for analysis Timing: May to August 2013luteum in the late secretory phase (the time of progesterone withdrawal), through menstruation culminating in post-menstrual repair of the endometrium in the proliferative phase, may be termed the “peri-menstrual” window and reflect the endocrine “luteo-follicular” transition period (FIGURE 1B). Of the 142 specimens, 59 (41. 4% cases. 3. Although the proliferation of the endometrium is part of a healthy cycle, things can go wrong during this phase. 41 as secretory phase, 15 as disordered proliferative endometrium, 6 as. At the end of this stage, around the 14th day, the. Disordered endometrial proliferation is associated with various conditions. The endometrium is generally assessed by ultrasound or MRI examination. Bleeding between periods. In these areas the abnormal glands should be focal. Among those women, 278 had a proliferative endometrium, and 684 had an atrophic endometrium. Endometrial hyperplasia tends to occur in people who are transitioning to menopause or who have gone through menopause. 1%) a mixture of non-secretory and secretory endometrium. A proliferative endometrium is a normal part of healthy uterine function when it occurs during the first half of the menstrual cycle. It occurs when the uterine lining grows atypically during the proliferative phase. Most patients tend to display a multiplicity of findings. Doctor of Medicine. 0 - Endometrial hyperplasia. 01 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Women with a proliferative endometrium were younger (61. cystically dilated glands are predominantly detected in the atrophic endometrium of postmenopausal women and in disordered proliferative endometrium, which is also. 85 FindingsDisordered proliferative endometrium is an exaggerated proliferative phase representing chronic anovulation in the perimenopausal years. At least she chatted to you as much as possible about the results. 00. 01 became effective on October 1, 2023. Disordered or dyssynchronous endometrium suggests ovulatory dysfunction. When your body prepares a layer of endometrial cells for attachment of a fertilized egg, that layer is called proliferative endometrium. Dr. N85. Norm S. 02 - Endometrial intraepithelial neoplasia [EIN]Pages in category "Endometrium" The following 15 pages are in this category, out of 15 total. Screening for endocervical or endometrial cancer. Furthermore, 962 women met the inclusion criteria. 13, 14 However, it maintains high T 2 WI signal. 7% patients, and proliferative phase pattern and. Admittedly, non-cycling proliferative lesions in the endometrium include those with an increased probability of developing into endometrial adenocarcinoma (atypical hyperplasia) and those running a limited risk of such progression (all other forms of endometrial hyperplasia and weakly proliferative endometrium). Proliferative Endometrium in Menopause: To Treat or Not to Treat? Obstet Gynecol. 9%) followed by disorder proliferative endometrium (15. 9%), disordered proliferative endometrium 200 (8. 7. HYPERPLASIA) VERSUS DISORDERED PROLIFERATIVE ENDOMETRIUM •All part of a spectrum •Probably no (at most minimal) risk of progression •Don’t worry too much about distinction- not clinically important (don’t let clinicians tell you it is) •Tend to call disordered proliferative in perimenopausal years; tend to call hyperplasia Also part of the differential diagnosis of simple hyperplasia are normal cycling endometrium, disordered proliferative phase, various compression artifacts, and chronic endometritis. It is a normal finding in women of reproductive age. Also, proliferative and secretory phase endometrium were seen only in 16. Endometrial hyperplasia (EH) comprises a spectrum of changes in the endometrium ranging from a slightly disordered pattern that exaggerates the. Learn about the symptoms, causes, and diagnosis of this condition from Healthline. Most useful feature to differentiate ECE and SPE is the accompanying stroma. Malignant lesion was not common and it comprised of only 1. 4: The uterine cycle begins with menstruation, which starts on day 1 of the cycle. Distinctly thinner endometrium than that in normal pregnant women is thus produced,. The pathognomonic feature of persistent estrogen stimulation is architectural changes of individual glands distributed randomly throughout the entire. 4. H&E stain. 8% cases in the present study, this is in contrast to other studies where a substantially higher incidence of 25. Among the normal cyclical patterns, the proliferative phase endometrium was documented as the commonest one in most of the studies except for the study done by Sajitha et al. Disordered or dyssynchronous endometrium suggests ovulatory dysfunction. Patients with proliferative/secretory endometrium — Proliferative/secretory endometrium is not a form of endometrial hyperplasia but suggests active estradiol secretion (eg, by adipose tissue; an estrogen-producing tumor) or exposure to exogenous estrogens and should be evaluated further. 65%). Proliferative endometrium on histopathology was the second most common diagnosis seen in 67 patients (30. Endometrium in proliferative phase, secretory phase, endometrial polyps, and disordered proliferative endometrium were studied for the presence of plasma cells. 0001) and had a higher body mass index (33. 2 vs 64. The pathognomonic feature is cystic changes of individual glands distributed randomly throughout the entire hormonally responsive region of the endometrium (superficial functionalis. More CD3 + T cells are in endometrium in the proliferative phase and equivalent numbers in the secretory phase of the cycle in women with disease compared to controls (Bulmer et al. 02 may differ. Plasma cells can be seen in disordered proliferative or breakdown endometrium in the absence of infection (Hum Pathol 2007;38:581) Spindled stromal cells Endometrial dating is unreliable due to frequent out of phase morphology (Am J Reprod Immunol 2011;66:410) Higher prevalence in proliferative phase (Reprod Biomed Online. 7% cases comparing favorably with 14% and 22% in other studies. Is there Chance of malignancy in future. 5%); other causes include benign endometrial polyp (11. In cases of endometrial. Our study provides preliminary evidence that the DNA flow. More African American women had a proliferative. 7% patients, and proliferative phase pattern and. N85. In disordered proliferative endometrium, the normal gland to stroma ratio is largely maintained although there may be focal mild glandular crowding. just reading about or looking for understanding of "weakly prolif endometrium" was part of my biopsy results. N85. The primary symptom of endometrial hyperplasia is abnormal menstrual bleeding. Obstetrics and Gynecology 20 years experience. Re: Disordered Proliferative Endometrium. Doctor has suggested wait & watch and 3 months progesterone treatment. 2 The risk of endometrial cancer is estimated to be less than 2% in this group. 75% and endometrial carcinoma in 11. During the menstrual cycle, the endometrium grows under the influence of two major hormones estrogen and progesterone. We studied the proliferative endometrium by analysing its transcriptome and by isolating, culturing and decidualizing EnSCs in vitro. Can you please suggest is the D&C report normal or not. and extending through the later, luteal, phase, progesterone elaborated. We planned to include in the analysis only first‐phase data from cross‐over trials. 0000000000005054. The 2024 edition of ICD-10-CM N85. We applied this latter technique for the first time on proliferative endometrial biopsies obtained during ovarian stimulation for in-cycle outcome prediction, in an attempt to overcome inter-cycle variability. 3. Obstetrics and Gynecology 27 years experience. However, in addition to numbers of cells, activation status is a critical part of assessing T-cell function, and this has been. Symptoms?: I assume this was a result of an endometrial biopsy done for heavy or irregular bleeding. 2 Secretory phase endometrium; 6. , 2011; Kurman et al. Jane Van Dis answered. 6. DDx: Endometrial hyperplasia with secretory changes. Endometrial hyperplasia is a condition that causes. Upper panels: images of endometrium in the proliferative phase (subject E1). N00-N99 - Diseases of the genitourinary system. Metaplasia in Endometrium is a common benign condition that occurs in the glands of the endometrial lining (of the uterus). The abnormal bleeding in the proliferative phase could be . Although the proliferation of the endometrium is part of a healthy cycle, things can go wrong during this phase. Symptoms?: I assume this was a result of an endometrial biopsy done for heavy or irregular bleeding. 2 Secretory phase endometrium; 6. Most of the patients were in age group. The endometrium in the background (a) shows secretory changes, but a gland in the central field of the left piece is an irregular cystic gland lined by proliferative-type epithelium (b). It results in an uncharacteristic thickening of the endometrium (lining of the uterus) The condition is also known as Endometrial Hyperplasia without Atypia. Disordered proliferative phase endometrium what is the medicine for this case? Dr. In the proliferative phase, the endometrium gradually thickens with an increase in E. Endometrial cells have an insufficient supply of glucose, leading to disordered endometrial development. Figure [Math Processing Error] 22. However, there is little literature and no evidence-based treatments for a finding of proliferative endometrium without atypia on Pipelle endometrial biopsy in women. 02. Pathological evaluation showed isolated RE (26 cases), to harbor polyps (19. Two cases of endometrial carcinomas were presented after the age 50 years. AUB-E proliferative phase endometrium and hyperplasia without atypia differs from normal proliferative endometrium by increased receptor expression. No nuclear atypia is seen, the nuclei being oval and maintaining their orientation to the underlying basement membrane. Hormonal or irritative stimuli are the main inducing factors of EMCs, although some metaplasias have a mutational origin. N80-N98 - Noninflammatory disorders of female genital tract. Endometrial hyperplasia is caused by an imbalance in the hormones involved in the normal menstrual cycle. What causes disordered endometrium?. In a study of 111 premenopausal women with abnormal uterine. The proliferative phase occurs after the menstrual phase during a period of tissue regeneration, in which the endometrium must repair itself and thicken. read more. 0001) and had a higher body mass index (33. There were only seven cases lacking endometrial activity. Disordered proliferative endometrium is an exaggeration of the normal proliferative phase; and, as such, much of the tissue is similar to that seen in normal proliferative endometrium. Ed Friedlander and 4 doctors agree. In premenopausal women, proliferative endometrial changes result from ovarian estrogen production during what we call the proliferative phase of the menstrual cycle. The FBLN1 protein is expressed in the stromal cells of human endometrial tissues and the FBLN1 mRNA levels are higher during the secretory phase than during the proliferative phase. Thickened: lining of your uterus: may be a hormone effect and responsive to oral contraceptives. Upper panels: images of endometrium in the proliferative phase (subject E1). This condition is detected through endometrial biopsy. Unlike endometrial polyp, fragments of anovulatory endometrium feature uniform and densely cellular stroma without fibrosis and lack thick-walled vessels. At this time, ultrasound exhibits a high echo. See moreDisordered proliferative endometrium is a benign condition of abnormal proliferative endometrium with architectural changes due to persistent unopposed estrogen stimulation. The main purpose of the endometrium is to provide an attachment site and a source of nourishment to an early embryo. Disordered proliferative endometrium accounted for 5. It is also seen in exogenous estrogen therapy and is a result of dys-synchronous growth of the functional is. Normal, no cancer,: but likely not ovulating, particularly if irregular or absent periods. Furthermore, 962 women met the inclusion criteria. Disordered proliferative endometrium ] is an exaggeration of the normal proliferative phase without significant increase in the overall ratio of glands to stroma and is due to persistent oestrogen stimulation. During the proliferative phase of cycle (day-5–14), the endometrium develops a trilaminar or striated appearance and measures 12–13 mm (10–16 mm) at ovulation. The uterine cycle is a series of events that occur to prepare the endometrium or inner lining of the uterus to be ready for possible implantation. Obstetrics and Gynecology 41 years experience. In some cases, the endometrium thickens too much, leading to excessive endometrial tissue in the. Cystic atrophy of the endometrium - does not have proliferative activity. Disordered proliferative endometrium is an exaggeration of the normal proliferative phase without significant increase in the overall ratio of glands to stroma and is due to persistent estrogen stimulation. Women with a proliferative endometrium were younger (61. 6. N85. IHC was done using syndecan-1. 6. Study of receptor. 1% of cases and these findings were consistent with findings in study done by Jetley et al. Relation to disordered proliferative endometrium. ICD-10-CM Coding Rules. Type 1 Excludes. A nested case-control study of EH progression, using extensive histopathology reports, concluded that AH was 14 times more likely to progress to endometrial carcinoma as compared to the women that presented with disordered proliferative endometrium without hyperplasia. 1%) each. Disclaimer: Information in questions answers, and. In this study, disordered proliferative endometrium was seen in 7. Patsouris E. This is the American ICD-10-CM version of N85. 2, 34 Endometrioid. The disordered proliferative phase pattern usually is an extension of anovulatory cycles due to persistent estrogen stimulation. The endometrium gradually thickens throughout menstrual cycle phases: from a thin 1–4 mm ET just after menstruation to 5–7 mm during proliferative phase, then up to 11 mm within the late proliferative (periovulatory) phase, to the maximal thickness during mid-secretory phase of up to 16 mm. The primary symptom of endometrial hyperplasia is abnormal menstrual bleeding. 7 Endometrium with changes due to exogenous hormones; 7. 8 is applicable to female patients. Cystically dilated glands with outpouchings. What do the results of my endometrial biopsy mean? Here are some words and phrases you might see on your biopsy results: Proliferative endometrium; Atrophic. Attention to the presence of artifacts (e. A slightly disordered endometrium is a form of cancer. Conclusions: The prevalence of abnormal uterine bleeding was found to be higher in comparison to other studies. 0: Endometrial polyp: 3:. Under the influence of local autocrine. Also part of the differential diagnosis of simple hyperplasia are normal cycling endometrium, disordered proliferative phase, various compression artifacts, and. 2%), disordered endometrium (19. Proliferative endometrium on the other hand was seen in only 6. Symptoms of both include pelvic pain and heavy. But disordered proliferative endometrium had only significant PR expression in stroma. Endometrial hyperplasia tends to occur in people who are transitioning to menopause or who have gone through menopause. 00 became effective on October 1, 2023. 2 Microscopic. 00 - other international versions of ICD-10 N85. 1 Images 3 Sign out 3. Specificity of 100% and sensitivity of 90% for detection of proliferative endometrium. Endometrial cells have an insufficient supply of glucose, leading to disordered endometrial development. Read More. 1 Proliferative phase endometrium; 6. One in three patients with adenomyosis is asymptomatic, but the rest may present with heavy. Created for people with ongoing healthcare needs but benefits everyone. There's been a Bank Holiday which usually delays issues. Only in postmenopaus: The endometrium is the lining of the uterus, and it 'proliferates' during the 1st 1/2 of the menstrual cycle under the influence of the estrogen that. Disordered proliferative endometrium; E. In the proliferative phase, the endometrium gradually thickens with an increase in E. Menstrual cycles (amount of time between periods) that are shorter than 21 days. (b) On CD10 immunohistochemistry, the stroma stains positive,. "Exodus" pattern is a term used to describe exfoliation of endometrial cells during the proliferative phase. 53 Atrophic endometrium 1 0. Endometrial hyperplasia is a condition that causes. We also analyzed 10 cases of disordered PE for Bcl-2 expression. Women with a proliferative endometrium were younger (61. 2; median, 2. Glands. 9. 00. Cystic atrophy of the endometrium - does not have proliferative activity. N85. Proliferative endometrium is a very common non-cancerous change that develops in the tissue lining the inside of the uterus. The majority of disordered proliferative endometrium had plasma cells (61% grade 1, 17% grade 2) all seen on methyl green pyronin staining only. IHC was done using syndecan-1. B. with tubal diagnosis condensation) phase metaplasia) Disordered proliferative endometrium endometrium. ICD-10-CM Coding Rules. Images Stromal staining of Ki67 was found to be more apparent in the secretory phase, however, it was found to be lower than that of the endometrial glands in the proliferative phase. 00 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Endometrial polyps (EMPs) are common exophytic masses associated with abnormal uterine bleeding and infertility. Discussion. Monoclonal growth and mutation of tumor-suppressor genes are measurable features of the premalignant phase of endometrial tumorigenesis that can be directly ascertained in paraffin-embedded tissues and correlated with histology on a case-by-case basis. This diagnosis means that after examining your tissue sample under the microscope, your pathologist saw irregular and dilated endometrial glands in the proliferative phase (growing phase). . A range of conditions. 5 - 40%) or secretory (4 - 7. 9 vs 30. Results: The most common histopathological pattern seen was proliferative phase (40%). In this situation the endometrium is proliferative but shows focal gland irregularities including dilatation and. Endometrial hyperplasia (EH) comprises a spectrum of changes in the endometrium ranging from a slightly disordered pattern that exaggerates the alterations seen in the late proliferative phase of the menstrual cycle to irregular, hyperchromatic lesions that are similar to endometrioid adenocarcinoma. The cells of the endometrium can proliferate abnormally, causing disordered proliferation. Henry Dorn answered. Plasma cells have also been noted in hormonally mediated endometrial disorders in association with gland architectural changes (“disordered proliferative” and “anovulatory” patterns), and stromal breakdown. Relation to disordered proliferative endometrium. 27: Irregular shedding: 5: 13: Endometrium hyperplasia: 21: 23. 3%). Among those women, 278 had a proliferative endometrium, and 684 had an atrophic endometrium. Cancer in situ of uterus; Cancer in situ, endometrium; Carcinoma in situ of uterus. Atrophy of uterus, acquired. Created for people with ongoing healthcare needs but benefits everyone. 1%), carcinoma (4. Disordered proliferative endometrium is a non-cancerous change that develops in the tissue that lines the inside of the uterus. Changes at the lower end of the histological spectrum are referred to as “disordered proliferative endometrium” (DPE), which describes a proliferative endometrium (PE) lacking the usual regularity of gland size and spacing. of PTEN protein in patients with endometrial intraepithelial neoplasia compared to endometrial adenocarcinoma and proliferative phase. 7. Instead, DPE is characterized by irregularly shaped, cystically dilated glands producing a disordered arrangement. The most common cause of uterine bleeding was found to be proliferative phase endometrium; that were 649 cases (56. Cytopathol. During the follicular or proliferative phase, estrogen signals for the cells lining the endometrium to multiply and for blood vessels to grow to supply the new layers of cells. , 2015). The endometrium gradually thickens throughout menstrual cycle phases: from a thin 1–4 mm ET just after menstruation to 5–7 mm during proliferative phase, then up to 11 mm within the late proliferative (periovulatory) phase, to the maximal thickness during mid-secretory phase of up to 16 mm. The occurrence of endometrial malignancy was remarkable, i. . 2%), irregular. g. [1] Libre Pathology separates the two. Cytological and histological examinations were conducted on 138 benign cases and 26 abnormal cases, including 24 cases with disordered proliferative phase (DOP) and 2 cases with simple endometrial. Two thirds of proliferative endometrium with breakdown showed plasma cells (19% grade 1,. Hence, it is also known as Metaplastic Changes in Endometrial Glands. Diagn. AE has shedding without gland dilation. Women of reproductive age: day 1 to 4 of the menstrual cycle: hyperechoic line measuring 1 to 4 mm early proliferative phase (day 5 to 13): hyperechoic line measuring 5 to 7 mm; late proliferative phase (day 14 to 16): multilayered appearance with. Very heavy periods. Mixed-phase endometrium. Based on an average 28-day menstrual cycle, proliferative endometrial changes may be divided into early (days 4–7), mid (days 8–10), and late (days 11–13) intervals. Absolutely not: Disordered proliferative endometrium solely describes endometrium that is in different phases of development of secretory glands at the same time. 01. Disordered proliferative endometrium characterized by few dilated and cystic (red arrow) glands amid tubular proliferative phase glands (blue arrow) (HE stain, ×10) ATROPHY Atrophy is an important cause of abnormal and recurrent uterine bleeding in postmenopausal patients, found in 25%–48% or more of menopausal women coming for a biopsy. 6%) cases. In 117 women with PCOS, endometrial histologic profiles are as follows: proliferative phase in 90 women (76. Biopsy proliferative phase endometrium with disorder features and focal stromal breakdown. The predominant endometrial histopathological finding was secretory endometrium 39cases (31. The other diagnoses, which accounted for the rest of the functional causes of atypical uterine bleeding, were disordered proliferative endometrium 15 cases (6. Endometrial hyperplasia was the most common histopathological finding and was seen in 25% patients, followed by secretory endometrium in 16. 1097/AOG. included disordered proliferative 26%, weakly proliferative 26%, inactive endometrium 26%, weakly secretory 07%, desynchronized endometrium 07% and simple hyperplasia 07%. 38% in the study by Sur D and Chakravorty R. It is also seen in exogenous estrogen therapy and is a result of dys-synchronous growth of the functional is.